Forschungsschwerpunkte

Wir beschäftigen uns mit folgenden Themen:

  • Genetische und funktionale Charakterisierung von Resistenzmechanismen bei Gram-negativen Bakterien
  • Molekulare Epidemiologie Gram-negativer Erreger nosokomialer Infektionen
  • Pathogenitätsfaktoren von Staphylococcus saprophyticus und Staphylococcus lugdunensis

Aktuelle Publikationen

2022:

Petrak F, Herpertz S, Hirsch J, Röhrig B, Donati-Hirsch I, Juckel G, Meier JJ, Gatermann S.:
Gut microbiota differs in composition between adults with type 1 diabetes with or without depression and healthy control participants: a case-control study.
BMC Microbiol. 2022 Jun 28;22(1):169.

Goer A, Blanchard LS, Van Belkum A, Loftus KJ, Armstrong TP, Gatermann SG, Shortridge D, Olson BJ, Meece JK, Fritsche TR, Pompilio M, Halimi D, Franceschi C.:
Multicenter Evaluation of the Novel ETEST Fosfomycin for Antimicrobial Susceptibility Testing of Enterobacterales, Enterococcus faecalis, and Staphylococcus Species.
J Clin Microbiol. 2022 Jun 23:e0002122.

Rössler H, Flasbeck V, Gatermann S, Brüne M.:
Alterations of the gut microbiota in borderline personality disorder.
J Psychosom Res. 2022 Jul;158:110942.

Gatermann S, Das S, Dubreuil L, Giske CG, Kahlmeter G, Lina G, Lindemann C, MacGowan A, Meletiadis J, Rossolini GM, Turnidge J, Cantón R.:
Expected phenotypes and expert rules are important complements to antimicrobial susceptibility testing.
Clin Microbiol Infect. 2022 Jun;28(6):764-767.

Bender JK, Haller S, Pfeifer Y, Hogardt M, Hunfeld KP, Thürmer A, Zanuzdana A, Werner M, Kunz B, Eisenberger D, Pfennigwerth N, Kempf VAJ, Werner G, Eckmanns T.:
Combined Clinical, Epidemiological, and Genome-Based Analysis Identified a Nationwide Outbreak of Burkholderia cepacia Complex Infections Caused by Contaminated Mouthwash Solutions.
Open Forum Infect Dis. 2022 Mar 9;9(5):ofac114.

Cremanns M, Lange F, Gatermann SG, Pfennigwerth N.:
Effect of sigma E on carbapenem resistance in OXA-48-producing Klebsiella pneumoniae.
J Antimicrob Chemother. 2022 May 29;77(6):1578-1585.

Schauer J, Gatermann SG, Eisfeld J, Hans JB, Ziesing S, Schlüter D, Pfennigwerth N.:
Characterization of GMB-1, a novel metallo-β-lactamase (MBL) found in three different Enterobacterales species.
J Antimicrob Chemother. 2022 Apr 27;77(5):1247-1253.

von Laer A, Eckmanns T, Zacher B, Pfennigwerth N, Gatermann SG, Reichert F, Diercke M, Steffen G, Altmann D, Reuss A.:
Geographical differences of carbapenem non-susceptible Enterobacterales and Acinetobacter spp. in Germany from 2017 to 2019.
Antimicrob Resist Infect Control. 2022 Feb 4;11(1):25.

2021:

Viehweger A, Blumenscheit C, Lippmann N, Wyres KL, Brandt C, Hans JB, Hölzer H, Irber L, Gatermann SG, Lübbert C, Pletz MW, Holt KE, König B:
Context-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae.
Microb Genom. 2021; 7(12): 000741.

Nockelmann L, Cremanns M, Gatermann SG, Pfennigwerth N.:
Evaluation of the rCIM for carbapenemase detection in Enterobacterales and Pseudomonas aeruginosa and description of the TSBrCIM, an optimized variant.
J Microbiol Methods. 2021 Nov;190:106345.

Hildebrandt A, Hökelekli O, Uflacker L, Rudolf H, Gatermann SG.:
COVID-19: Hotspot hospital?- seroprevalence of SARS-CoV-2 antibodies in hospital employees in a secondary care hospital network in Germany: Intermediate results of a prospective surveillance study.
Int J Hyg Environ Health. 2021 Jun;235:113771.

Kresken M, Korte-Berwanger M, Pfennigwerth N, Gatermann SG; Working Party Antimicrobial Resistance of the Paul-Ehrlich-Society for Chemotherapy:
In vitro activity of ceftazidime/avibactam against ceftazidime-resistant Enterobacterales and Pseudomonas aeruginosa from hospitalised patients in Germany.
J Glob Antimicrob Resist. 2021 Jun;25:337-338.

2020:

Heiden SE, Hübner NO, Bohnert JA, Heidecke CD, Kramer A, Balau V, Gierer W, Schaefer S, Eckmanns T, Gatermann S, Eger E, Guenther S, Becker K, Schaufler K.:
A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition.
Genome Med. 2020 Dec 9;12(1):113.

Lötsch F, Albiger B, Monnet DL, Struelens MJ, Seifert H, Kohlenberg A; European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) carbapenem-resistant Acinetobacter baumannii capacity survey group; EURGen-Net carbapenem-resistant Acinetobacter baumannii capacity survey group.:
Epidemiological situation, laboratory capacity and preparedness for carbapenem-resistant Acinetobacter baumannii in Europe, 2019.
Euro Surveill. 2020 Nov;25(45):2001735.

David S, Cohen V, Reuter S, Sheppard AE, Giani T, Parkhill J; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group; ESCMID Study Group for Epidemiological Markers (ESGEM), Rossolini GM, Feil EJ, Grundmann H, Aanensen DM.:
Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among Klebsiella pneumoniae.
Proc Natl Acad Sci USA. 2020 Oct 6;117(40):25043-25054.

Pfennigwerth N, Gatermann SG, Körber-Irrgang B, Hönings R:
Phenotypic detection and differentiation of carbapenemase classes including OXA-48-like enzymes in Enterobacterales and Pseudomonas aeruginosa by a highly specialized MICRONAUT-S microdilution assay.
J Clin Microbiol. 2020 Oct 21;58(11):e00171-20.

Kahlmeter G, Cantón R, Giske CG, Turnidge J; EUCAST Steering Committee:
Re: In the name of common sense: EUCAST breakpoints and potential pitfalls. National dissemination of EUCAST guidelines is a shared responsibility.
Clin Microbiol Infect. 2020 Aug 19:S1198-743X(20)30489-4. Online ahead of print.

Kresken M, Korte-Berwanger M, Gatermann SG, Pfeifer Y, Pfennigwerth N, Seifert H, Werner G:
In vitro activity of cefiderocol against aerobic Gram-negative bacterial pathogens from Germany.
Int J Antimicrob Agents. 2020 Oct;56(4):106128.

Kremer K, Kramer R, Neumann B, Haller S, Pfennigwerth N, Werner G, Gatermann S, Schroten H, Eckmanns T, Hans JB:
Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020.
Euro Surveill. 2020 Jun;25(25):2000923.

Wantia N, Gatermann SG, Rothe K, Laufenberg R:
New EUCAST definitions of S, I and R from 2019 - German physicians are largely not aware of the changes.
Infection. 2020 Aug;48(4):597-606.

Ludden C, Lötsch F, Alm E, Kumar N, Johansson K, Albiger B, Huang TD, Denis O, Hammerum AM, Hasman H, Jalava J, Räisänen K, Dortet L, Jousset AB, Gatermann S, Haller S, Cormican M, Brennan W, Del Grosso M, Monaco M, Schouls L, Samuelsen Ø, Pirš M, Cerar T, Oteo-Iglesias J, Pérez-Vázquez M, Sjöström K, Edquist P, Hopkins KL, Struelens MJ, Palm D, Monnet DL, Kohlenberg A:
Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019.
Euro Surveill. 2020 May;25(20):2000627.

Kresken M, Körber-Irrgang B, Korte-Berwanger M, Pfennigwerth N, Gatermann SG, Seifert H; German Carbapenem Resistance Study Group:
Dissemination of carbapenem-resistant Pseudomonas aeruginosa isolates and their susceptibilities to ceftolozane-tazobactam in Germany.
Int J Antimicrob Agents. 2020 Jun;55(6):105959.

Duscha A, Gisevius B, Hirschberg S, Yissachar N, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Sthler K, Hirche F, Balogh A, Kempa S, Tröger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, Haghikia A:
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.
Cell. 2020 Mar 19;180(6):1067-1080.e16

Poirel L, Nordmann P, de la Rosa JMO, Kutateladze M, Gatermann S, Corbellino M:
A phage-based decolonisation strategy against pan-resistant enterobacterial strains.
Lancet Infect Dis. 2020 May;20(5):525-526.

Hegelmaier T, Lebbing M, Duscha A, Tomaske L, T�nges L, Holm JB, Björn Nielsen H, Gatermann SG, Przuntek H, Haghikia A:
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson's Disease.
Cells. 2020 Feb 6;9(2).

Laufenberg Née Kohlmann R, Gatermann SG:
Species-specific epidemiology of AmpC production.
Clin Infect Dis. 2020 Feb 5:ciaa120.

Schauer J, Gatermann SG, Hoffmann D, Hupfeld L, Pfennigwerth N:
GPC-1, a novel class A carbapenemase found in a clinical Pseudomonas aeruginosa isolate.
J Antimicrob Chemother. 2020 Apr 1;75(4):911-916.

2019:

Weber RE, Pietsch M, Frühauf A, Pfeifer Y, Martin M, Luft D, Gatermann S, Pfennigwerth N, Kaase M, Werner G, Fuchs S:
IS26-Mediated Transfer of blaNDM-1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital.
Front Microbiol. 2019 Dec 17;10:2817. doi: 10.3389/fmicb.2019.02817. eCollection 2019.

Schäfer E, Malecki M, Tellez-Castillo CJ, Pfennigwerth N, Marlinghaus L, Higgins PG, Mattner F, Wendel AF:
Molecular surveillance of carbapenemase-producing Pseudomonas aeruginosa at three medical centres in Cologne, Germany.
Antimicrob Resist Infect Control. 2019 Dec 30;8:208. doi: 10.1186/s13756-019-0665-5. eCollection 2019.

David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, Abudahab K, Goater R, Giani T, Errico G, Aspbury M, Sjunnebo S; EuSCAPE Working Group; ESGEM Study Group, Feil EJ, Rossolini GM, Aanensen DM, Grundmann H:
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread.
Nat Microbiol. 2019 Nov;4(11):1919-1929. doi: 10.1038/s41564-019-0492-8. Epub 2019 Jul 29.

Haller S, Kramer R, Becker K, Bohnert JA, Eckmanns T, Hans JB, Hecht J, Heidecke CD, H�bner NO, Kramer A, Klaper K, Littmann M, Marlinghaus L, Neumann B, Pfeifer Y, Pfennigwerth N, Rogge S, Schaufler K, Thürmer A, Werner G, Gatermann S:
Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019.
Euro Surveill. 2019 Dec;24(50). doi: 10.2807/1560-7917.ES.2019.24.50.1900734.

Lucena Baeza L, Pfennigwerth N, Hamprecht A.:
Rapid and Easy Detection of Carbapenemases in Enterobacterales in the Routine Laboratory Using the New GenePOC Carba/Revogene Carba C Assay.
J Clin Microbiol. 2019 Aug 26;57(9).

Klare I, Bender JK, Fleige C, Kriebel N, Hamprecht A, Gatermann S, Werner G:
Comparison of VITEK® 2, three different gradient strip tests and broth microdilution for detecting vanB-positive Enterococcus faecium isolates with low vancomycin MICs.
J Antimicrob Chemother. 2019 Oct 1;74(10):2926-2929.

Schauer J, Gatermann SG, Marschal M, Pfennigwerth N:
Genetic and biochemical characterization of FRI-3, a novel variant of the Ambler class A carbapenemase FRI-1.
J Antimicrob Chemother. 2019 Oct 1;74(10):2891-2894.

Belda-Orlowski A, Pfennigwerth N, Gatermann SG, Korte-Berwanger M:
Evaluation and readout optimization of the rapid polymyxin NP test for the detection of colistin-resistant Enterobacteriaceae.
J Med Microbiol. 2019 Aug;68(8):1189-1193.

Kohlmann R, Bähr T, Gatermann SG:
Effect of ampC derepression on cefepime MIC in Enterobacterales with chromosomally encoded inducible AmpC β-lactamase.
Clin Microbiol Infect. 2019 Sep;25(9):1158.e1-1158.e4.

Pfennigwerth N, Kaminski A, Korte-Berwanger M, Pfeifer Y, Simon M, Werner G, Jantsch J, Marlinghaus L, Gatermann SG:
Evaluation of six commercial products for colistin susceptibility testing in Enterobacterales.
Clin Microbiol Infect. 2019 Nov;25(11):1385-1389.

Baeza LL, Pfennigwerth N, Greissl C, Göttig S, Saleh A, Stelzer Y, Gatermann SG, Hamprecht A:
Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm.
Clin Microbiol Infect. 2019 Oct;25(10):1286.e9-1286.e15.

Lange F, Pfennigwerth N, Höfken LM, Gatermann SG, Kaase M:
Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs.
J Antimicrob Chemother. 2019 Mar 1;74(3):571-576.

Rösner S, Kamalanabhaiah S, Kösters U, Kolbert M, Pfennigwerth N, Mack D:
Evaluation of a novel immunochromatographic lateral flow assay for rapid detection of OXA-48, NDM, KPC and VIM carbapenemases in multidrug-resistant Enterobacteriaceae.
J Med Microbiol. 2019 Mar;68(3):379-381.

Topoulos S, Giesa C, Gatermann S, Fussen R, Lemmen S, Ewig S:
Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.
Infection. 2019 Jun;47(3):425-433.

Simon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J:
Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales.
J Microbiol Methods. 2019 Jan;156:29-33.

Hommelsheim C, Sichau M, Heipel R, Müller E, Gatermann S, Pfeifer M, Ewig S:
Predictors of Outcomes in Patients with Prolonged Weaning with Focus on Respiratory Tract Pathogens and Infection.
Respiration. 2019;97(2):135-144. doi: 10.1159/000493430. Epub 2018 Oct 17.

Brolund A, Lagerqvist N, Byfors S, Struelens MJ, Monnet DL, Albiger B, Kohlenberg A; European Antimicrobial Resistance Genes Surveillance Network EURGen-Net Capacity Survey Group.:
Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018.
Euro Surveill. 2019 Feb;24(9). doi: 10.2807/1560-7917.ES.2019.24.9.1900123.

2018:

Steffen G, Pietsch M, Kaase M, Gatermann S, Werner G, Fuchs S, Pfeifer Y, Schmitt W, Adam H, Eckmanns T, Haller S:
Overestimation of an outbreak of Enterobacter cloacae in a neonatal intensive care unit in Germany, 2015.
Pediatr Infect Dis J. 2018 Dec 13. doi: 10.1097/INF.0000000000002264. [Epub ahead of print]

Lange F, Pfennigwerth N, Hartl R, Kerschner H, Achleitner D, Gatermann SG, Kaase M:
LMB-1, a novel family of class B3 MBLs from an isolate of Enterobacter cloacae.
J Antimicrob Chemother. 2018 Sep 1;73(9):2331-2335

Kohlmann R, Bähr T, Gatermann SG:
Species-specific mutation rates for ampC derepression in Enterobacterales with chromosomally encoded inducible AmpC β-lactamase.
J Antimicrob Chemother. 2018 Jun 1;73(6):1530-1536.

Rösner S, Gehlweiler K, Küsters U, Kolbert M, Hübner K, Pfennigwerth N, Mack D:
Comparison of two commercial carbapenemase gene confirmatory assays in multiresistant Enterobacteriaceae and Acinetobacter baumannii-complex.
PLoS One. 2018 May 21;13(5):e0197839.

Becker L, Kaase M, Pfeifer Y, Fuchs S, Reuss A, von Laer A, Sin MA, Korte-Berwanger M, Gatermann S, Werner G:
Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014.
Antimicrob Resist Infect Control. 2018 May 2;7:62.

Simon M, Richert K, Pfennigwerth N, Pfeifer Y, Reischl U, Gatermann S, Gessner A, Jantsch J:
Carbapenemase detection using the β-CARBA test: Influence of test conditions on performance and comparison with the RAPIDEC CarbaNP assay.
J Microbiol Methods. 2018 Apr;147:17-19.

van Almsick V, Ghebremedhin B, Pfennigwerth N, Ahmad-Nejad P:
Rapid detection of carbapenemase-producing Acinetobacter baumannii and carbapenem-resistant Enterobacteriaceae using a bioluminescence-based phenotypic method.
J Microbiol Methods. 2018 Apr;147:20-25.

Hagemann JB, Pfennigwerth N, Gatermann SG, von Baum H, Essig A:
KPC-2 carbapenemase-producing Pseudomonas aeruginosa reaching Germany.
J Antimicrob Chemother. 2018 Mar 24. doi: 10.1093/jac/dky105. [Epub ahead of print]

Schaumburg F, Becker K, Gatermann SG:
Guidelines for Interpretation Required.
Dtsch Arztebl Int. 2018 Mar 16;115(11):191.

Becker L, Fuchs S, Pfeifer Y, Semmler T, Eckmanns T, Korr G, Sissolak D, Friedrichs M, Zill E, Tung ML, Dohle C, Kaase M, Gatermann S, Rüssmann H, Steglich M, Haller S, Werner G:
Whole Genome Sequence Analysis of CTX-M-15 Producing Klebsiella Isolates Allowed Dissecting a Polyclonal Outbreak Scenario.
Front Microbiol. 2018 Feb 23;9:322.

Sobke A, Makarewicz O, Baier M, Bär C, Pfister W, Gatermann SG, Pletz MW, Forstner C:
Empirical treatment of lower urinary tract infections in the face of spreading multidrug resistance: in vitro study on the effectiveness of nitroxoline.
Int J Antimicrob Agents. 2018 Feb;51(2):213-220.

2017:

Lange F, Pfennigwerth N, Gerigk S, Gohlke F, Oberdorfer K, Purr I, Wohanka N, Roggenkamp A, Gatermann SG, Kaase M:
Dissemination of blaOXA-58 in Proteus mirabilis isolates from Germany.
J Antimicrob Chemother. 2017 May 1;72(5):1334-1339.

Pfennigwerth N, Lange F, Belmar Campos C, Hentschke M, Gatermann SG, Kaase M:
Genetic and biochemical characterization of HMB-1, a novel subclass B1 metallo-β-lactamase found in a Pseudomonas aeruginosa clinical isolate.
J Antimicrob Chemother. 2017 Apr 1;72(4):1068-1073.

Koroska F, Göttig S, Kaase M, Steinmann J, Gatermann S, Sommer J, Wille T, Plum G, Hamprecht A:
Comparison of Phenotypic Tests and an Immunochromatographic Assay and Development of a New Algorithm for Detection of OXA-48-like Carbapenemases.
J Clin Microbiol. 2017 Mar;55(3):877-883.

Wendel AF, Kaase M, Autenrieth IB, Peter S, Oberhettinger P, Rieber H, Pfeffer K, MacKenzie CR, Willmann M:
Protracted Regional Dissemination of GIM-1-Producing Serratia marcescens in Western Germany.
Antimicrob Agents Chemother. 2017 Feb 23;61(3).

Grundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasević AT, Cantón R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group:
Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study.
Lancet Infect Dis. 2017 Feb;17(2):153-163.