Forschungsschwerpunkte

Wir beschäftigen uns mit folgenden Themen:

  • Genetische und funktionale Charakterisierung von Carbapenemasen
  • Charakterisierung weiterer Carbapenemresistenzmechanismen
  • Molekulare Epidemiologie Gram-negativer Erreger nosokomialer Infektionen
  • Pathogenitätsfaktoren von Staphylococcus saprophyticus und Staphylococcus lugdunensis
  • Epidemiologie von methicillin-resistenten Staphylococcus aureus (MRSA)

Aktuelle Publikationen

2019:

Pfennigwerth N, Kaminski A, Korte-Berwanger M, Pfeifer Y, Simon M, Werner G, Jantsch J, Marlinghaus L, Gatermann SG:
Evaluation of six commercial products for colistin susceptibility testing in Enterobacterales.
Clin Microbiol Infect. 2019 Mar 27. pii: S1198-743X(19)30119-3. doi: 10.1016/j.cmi.2019.03.017. [Epub ahead of print]

Baeza LL, Pfennigwerth N, Greissl C, Göttig S, Saleh A, Stelzer Y, Gatermann SG, Hamprecht A:
Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm.
Clin Microbiol Infect. 2019 Mar 18. pii: S1198-743X(19)30104-1. doi: 10.1016/j.cmi.2019.03.003. [Epub ahead of print]

Lange F, Pfennigwerth N, Höfken LM, Gatermann SG, Kaase M:
Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs.
J Antimicrob Chemother. 2019 Mar 1;74(3):571-576.

Rösner S, Kamalanabhaiah S, Küsters U, Kolbert M, Pfennigwerth N, Mack D:
Evaluation of a novel immunochromatographic lateral flow assay for rapid detection of OXA-48, NDM, KPC and VIM carbapenemases in multidrug-resistant Enterobacteriaceae.
J Med Microbiol. 2019 Mar;68(3):379-381.

Topoulos S, Giesa C, Gatermann S, Fussen R, Lemmen S, Ewig S:
Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.
Infection. 2019 Jan 16. doi: 10.1007/s15010-018-1262-x. [Epub ahead of print]

Simon M, Gatermann S, Pfeifer Y, Reischl U, Gessner A, Jantsch J:
Evaluation of the automated BD Phoenix CPO Detect panel in combination with the β-CARBA assay for detection and classification of carbapenemase-producing Enterobacterales.
J Microbiol Methods. 2019 Jan;156:29-33. doi: 10.1016/j.mimet.2018.11.024. Epub 2018 Dec 3.

Hommelsheim C, Sichau M, Heipel R, Müller E, Gatermann S, Pfeifer M, Ewig S:
Predictors of Outcomes in Patients with Prolonged Weaning with Focus on Respiratory Tract Pathogens and Infection.
Respiration. 2019;97(2):135-144. doi: 10.1159/000493430. Epub 2018 Oct 17.

2018:

Steffen G, Pietsch M, Kaase M, Gatermann S, Werner G, Fuchs S, Pfeifer Y, Schmitt W, Adam H, Eckmanns T, Haller S:
Overestimation of an outbreak of Enterobacter cloacae in a neonatal intensive care unit in Germany, 2015.
Pediatr Infect Dis J. 2018 Dec 13. doi: 10.1097/INF.0000000000002264. [Epub ahead of print]

Lange F, Pfennigwerth N, Hartl R, Kerschner H, Achleitner D, Gatermann SG, Kaase M:
LMB-1, a novel family of class B3 MBLs from an isolate of Enterobacter cloacae.
J Antimicrob Chemother. 2018 Sep 1;73(9):2331-2335

Kohlmann R, Bähr T, Gatermann SG:
Species-specific mutation rates for ampC derepression in Enterobacterales with chromosomally encoded inducible AmpC β-lactamase.
J Antimicrob Chemother. 2018 Jun 1;73(6):1530-1536.

Rösner S, Gehlweiler K, Küsters U, Kolbert M, Hübner K, Pfennigwerth N, Mack D:
Comparison of two commercial carbapenemase gene confirmatory assays in multiresistant Enterobacteriaceae and Acinetobacter baumannii-complex.
PLoS One. 2018 May 21;13(5):e0197839.

Becker L, Kaase M, Pfeifer Y, Fuchs S, Reuss A, von Laer A, Sin MA, Korte-Berwanger M, Gatermann S, Werner G:
Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014.
Antimicrob Resist Infect Control. 2018 May 2;7:62.

Simon M, Richert K, Pfennigwerth N, Pfeifer Y, Reischl U, Gatermann S, Gessner A, Jantsch J:
Carbapenemase detection using the β-CARBA test: Influence of test conditions on performance and comparison with the RAPIDEC CarbaNP assay.
J Microbiol Methods. 2018 Apr;147:17-19.

van Almsick V, Ghebremedhin B, Pfennigwerth N, Ahmad-Nejad P:
Rapid detection of carbapenemase-producing Acinetobacter baumannii and carbapenem-resistant Enterobacteriaceae using a bioluminescence-based phenotypic method.
J Microbiol Methods. 2018 Apr;147:20-25.

Hagemann JB, Pfennigwerth N, Gatermann SG, von Baum H, Essig A:
KPC-2 carbapenemase-producing Pseudomonas aeruginosa reaching Germany.
J Antimicrob Chemother. 2018 Mar 24. doi: 10.1093/jac/dky105. [Epub ahead of print]

Schaumburg F, Becker K, Gatermann SG:
Guidelines for Interpretation Required.
Dtsch Arztebl Int. 2018 Mar 16;115(11):191.

Becker L, Fuchs S, Pfeifer Y, Semmler T, Eckmanns T, Korr G, Sissolak D, Friedrichs M, Zill E, Tung ML, Dohle C, Kaase M, Gatermann S, Rüssmann H, Steglich M, Haller S, Werner G:
Whole Genome Sequence Analysis of CTX-M-15 Producing Klebsiella Isolates Allowed Dissecting a Polyclonal Outbreak Scenario.
Front Microbiol. 2018 Feb 23;9:322.

Sobke A, Makarewicz O, Baier M, Bär C, Pfister W, Gatermann SG, Pletz MW, Forstner C:
Empirical treatment of lower urinary tract infections in the face of spreading multidrug resistance: in vitro study on the effectiveness of nitroxoline.
Int J Antimicrob Agents. 2018 Feb;51(2):213-220.

2017:

Lange F, Pfennigwerth N, Gerigk S, Gohlke F, Oberdorfer K, Purr I, Wohanka N, Roggenkamp A, Gatermann SG, Kaase M:
Dissemination of blaOXA-58 in Proteus mirabilis isolates from Germany.
J Antimicrob Chemother. 2017 May 1;72(5):1334-1339.

Pfennigwerth N, Lange F, Belmar Campos C, Hentschke M, Gatermann SG, Kaase M:
Genetic and biochemical characterization of HMB-1, a novel subclass B1 metallo-β-lactamase found in a Pseudomonas aeruginosa clinical isolate.
J Antimicrob Chemother. 2017 Apr 1;72(4):1068-1073.

Koroska F, Göttig S, Kaase M, Steinmann J, Gatermann S, Sommer J, Wille T, Plum G, Hamprecht A:
Comparison of Phenotypic Tests and an Immunochromatographic Assay and Development of a New Algorithm for Detection of OXA-48-like Carbapenemases.
J Clin Microbiol. 2017 Mar;55(3):877-883.

Wendel AF, Kaase M, Autenrieth IB, Peter S, Oberhettinger P, Rieber H, Pfeffer K, MacKenzie CR, Willmann M:
Protracted Regional Dissemination of GIM-1-Producing Serratia marcescens in Western Germany.
Antimicrob Agents Chemother. 2017 Feb 23;61(3).

Grundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasević AT, Cantón R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group:
Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study.
Lancet Infect Dis. 2017 Feb;17(2):153-163.

2016:

Kohlmann R, Gatermann SG:
Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data--The Influence of Different Parameters in a Routine Clinical Microbiology Laboratory.
PLoS One. 2016 Jan 27;11(1):e0147965.

Marlinghaus L, Huß M, Korte-Berwanger M, Sakinc-Güler T, Gatermann SG:
D-serine transporter in Staphylococcus saprophyticus identified.
FEMS Microbiol Lett. 2016 Jul;363(14).

Kaase M, Schimanski S, Schiller R, Beyreiß B, Thürmer A, Steinmann J, Kempf VA, Hess C, Sobottka I, Fenner I, Ziesing S, Burckhardt I, von Müller L, Hamprecht A, Tammer I, Wantia N, Becker K, Holzmann T, Furitsch M, Volmer G, Gatermann SG:
Multicentre investigation of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in German hospitals.
Int J Med Microbiol. 2016 Sep;306(6):415-20.

Kohlmann R, Barenberg K, Anders A, Gatermann SG:
Acetobacter indonesiensis Bacteremia in Child with Metachromatic Leukodystrophy.
Emerg Infect Dis. 2016 Sep;22(9):1681-3.